Proteomic Shotgun and Targeted Mass Spectrometric Datasets of Cerebrospinal Fluid (Liquor) Derived from Patients with Vestibular Schwannoma

Vestibular schwannomas are relatively rare intracranial tumors compared to other brain tumors. Data on the molecular features, especially schwannoma proteome, scarce. The 41 cerebrospinal fluid (liquor) samples were obtained during surgical removal of vestibular schwannoma. Obtained peptide analyzed by shotgun LC-MS/MS high-resolution mass spectrometry. same spiked with 148 stable isotopically labeled standards (SIS) followed alkaline fractionation and scheduled multiple reaction monitoring (MRM) for quantitative analysis. natural counterparts SIS peptides mapped onto 111 proteins that Food Drug Administration (FDA)-approved diagnostic use. As a result, 525 identified high confidence (at least two per protein, FDR < 1%) in liquor samples. Absolute concentrations 54 FDA-approved detected at five experimental Since there is lack data landscape schwannoma, datasets unique one first its field.